Understanding Lymphangiogenesis in Knockout Models, the Cornea, and Ocular Diseases for the Development of Therapeutic Interventions
Identifieur interne : 001651 ( Main/Exploration ); précédent : 001650; suivant : 001652Understanding Lymphangiogenesis in Knockout Models, the Cornea, and Ocular Diseases for the Development of Therapeutic Interventions
Auteurs : Jessica F. Yang ; Amit Walia ; Yu-Hui Huang ; Kyu-Yeon Han ; Mark I. Rosenblatt ; Dimitri T. Azar ; Jin-Hong ChangSource :
- Survey of ophthalmology [ 0039-6257 ] ; 2015.
Abstract
A major focus of cancer research for several decades has been understanding the ability of tumors to induce new blood vessel formation, a process known as angiogenesis. Unfortunately, only limited success has been achieved in the clinical application of angiogenesis inhibitors. We now know that lymphangiogenesis, the growth of lymphatic vessels, likely also plays a major role in tumor progression. Thus, therapeutic strategies targeting lymphangiogenesis or both lymphangiogenesis and angiogenesis may represent promising approaches for treating cancer and other diseases. Importantly, research progress toward understanding lymphangiogenesis is significantly behind that related to angiogenesis. A PubMed search of ‘angiogenesis’ returns nearly 80,000 articles, whereas a search of ‘lymphangiogenesis’ returns approximately 2,635 articles. This stark contrast can be explained by the lack of molecular markers for identifying the invisible lymphatic vasculature that persisted until less than two decades ago combined with the intensity of research interest in angiogenesis during the past half-century. Still, significant strides have been made in developing strategies to modulate lymphangiogenesis, largely using ocular disease models. Here, we review the current knowledge of lymphangiogenesis in the context of knockout models, ocular diseases, the biology of activators and inhibitors, and the potential for therapeutic interventions targeting this process.
Url:
DOI: 10.1016/j.survophthal.2015.12.004
PubMed: 26706194
PubMed Central: 4835265
Affiliations:
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Yang</name></author><author><name sortKey="Walia, Amit" sort="Walia, Amit" uniqKey="Walia A" first="Amit" last="Walia">Amit Walia</name></author><author><name sortKey="Huang, Yu Hui" sort="Huang, Yu Hui" uniqKey="Huang Y" first="Yu-Hui" last="Huang">Yu-Hui Huang</name></author><author><name sortKey="Han, Kyu Yeon" sort="Han, Kyu Yeon" uniqKey="Han K" first="Kyu-Yeon" last="Han">Kyu-Yeon Han</name></author><author><name sortKey="Rosenblatt, Mark I" sort="Rosenblatt, Mark I" uniqKey="Rosenblatt M" first="Mark I" last="Rosenblatt">Mark I. Rosenblatt</name></author><author><name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name></author><author><name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name></author></analytic><series><title level="j">Survey of ophthalmology</title><idno type="ISSN">0039-6257</idno><idno type="eISSN">1879-3304</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">A major focus of cancer research for several decades has been understanding the ability of tumors to induce new blood vessel formation, a process known as angiogenesis. Unfortunately, only limited success has been achieved in the clinical application of angiogenesis inhibitors. We now know that lymphangiogenesis, the growth of lymphatic vessels, likely also plays a major role in tumor progression. Thus, therapeutic strategies targeting lymphangiogenesis or both lymphangiogenesis and angiogenesis may represent promising approaches for treating cancer and other diseases. Importantly, research progress toward understanding lymphangiogenesis is significantly behind that related to angiogenesis. A PubMed search of ‘angiogenesis’ returns nearly 80,000 articles, whereas a search of ‘lymphangiogenesis’ returns approximately 2,635 articles. This stark contrast can be explained by the lack of molecular markers for identifying the invisible lymphatic vasculature that persisted until less than two decades ago combined with the intensity of research interest in angiogenesis during the past half-century. Still, significant strides have been made in developing strategies to modulate lymphangiogenesis, largely using ocular disease models. Here, we review the current knowledge of lymphangiogenesis in the context of knockout models, ocular diseases, the biology of activators and inhibitors, and the potential for therapeutic interventions targeting this process.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name><name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name><name sortKey="Han, Kyu Yeon" sort="Han, Kyu Yeon" uniqKey="Han K" first="Kyu-Yeon" last="Han">Kyu-Yeon Han</name><name sortKey="Huang, Yu Hui" sort="Huang, Yu Hui" uniqKey="Huang Y" first="Yu-Hui" last="Huang">Yu-Hui Huang</name><name sortKey="Rosenblatt, Mark I" sort="Rosenblatt, Mark I" uniqKey="Rosenblatt M" first="Mark I" last="Rosenblatt">Mark I. Rosenblatt</name><name sortKey="Walia, Amit" sort="Walia, Amit" uniqKey="Walia A" first="Amit" last="Walia">Amit Walia</name><name sortKey="Yang, Jessica F" sort="Yang, Jessica F" uniqKey="Yang J" first="Jessica F." last="Yang">Jessica F. Yang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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